A convenient synthesis of 3-fluorothiophene

Article abstract of DOI:10.1080/00397919408012631

2-bromo-3-chlorothiophene 2 underwent nucleophilic aromatic substitution using cyanocupper to give 2-cyano-3-chlorothiophene 3 which, after fluoration with CsF, hydrolysis and decarboxylation gave 3-fluorothiophene 6 in good yield. The electropolymerisation of 6 is also described.

Full text of DOI:10.1080/00397919408012631

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Synthetic Communications: An
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A Convenient Synthesis of 3-
Fluorothiophene
Ahmed El Kassmi a , Fabienne Fache a & Marc
Lemaire a
a Université Claude Bernard Lyon I, Laboratoire de
Catalyse et Synthèse Organique, U.P. C.N.R.S. , n°
5401, B[acaron]t. 308, 43 bd du 11 novembre 1918,
69622, Villeurbanne CEDEX, France
Published online: 23 Sep 2006.
To cite this article: Ahmed El Kassmi , Fabienne Fache & Marc Lemaire (1994)
A Convenient Synthesis of 3-Fluorothiophene, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 24:1,
95-101, DOI: 10.1080/00397919408012631
To link to this article: http://dx.doi.org/10.1080/00397919408012631
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