Chiral Mercaptoaryl-oxazolines as Ligands in Asymmetric Catalysis: Enantioselective Cu-Catalyzed 1,4-Addition of Grignard Reagents to α,β-Unsaturated Ketones

Article abstract of DOI:10.1016/S0040-4039(00)61549-6

Copper(I) thiolate complexes derived from chiral mercaptophenyl-oxazolines 3 have been studied as enantioselective catalysts for the 1,4-addition of Grignard reagents to α,β-unsaturated ketones.For cyclic enones enantioselectivities increase in the sequen