A NOVEL SYNTHETIC METHOD OF HMG-CoA REDUCTASE INHIBITOR NK-104 VIA HYDROBORATION-CROSS COUPLING SEQUENCE

DOI: 10.1016/S0040-4039(00)61407-7

Source and publish data:

Tetrahedron Letters p. 8267 - 8270 (1993)

Update date:2022-08-05

Topics:

Authors:

Miyachi, Nobuhide

Yanagawa, Yoshinobu

Iwasaki, Hiroshi

Ohara, Yoshio

Hiyama, Tamejiro

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Article abstract of DOI:10.1016/S0040-4039(00)61407-7

The regioselective hydroboration of ethyl (3R,5S)-3,5-isopropylidenedioxy-6-heptynoate, followed by the cross-coupling reaction with an aryl halide, provides ethyl (3R,5S,6E)-7-aryl-3,5-isopropylidenedioxy-6-heptenoate, a precursor of a highly potent HMG-

Full text of DOI:10.1016/S0040-4039(00)61407-7

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