A NOVEL SYNTHETIC METHOD OF HMG-CoA REDUCTASE INHIBITOR NK-104 VIA HYDROBORATION-CROSS COUPLING SEQUENCE

DOI: 10.1016/S0040-4039(00)61407-7

Source and publish data:

Tetrahedron Letters p. 8267 - 8270 (1993)

Update date:2022-08-05

Topics:

Authors:

Miyachi, Nobuhide

Yanagawa, Yoshinobu

Iwasaki, Hiroshi

Ohara, Yoshio

Hiyama, Tamejiro

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)61407-7

The regioselective hydroboration of ethyl (3R,5S)-3,5-isopropylidenedioxy-6-heptynoate, followed by the cross-coupling reaction with an aryl halide, provides ethyl (3R,5S,6E)-7-aryl-3,5-isopropylidenedioxy-6-heptenoate, a precursor of a highly potent HMG-

Full text of DOI:10.1016/S0040-4039(00)61407-7

Products guided by the article

Product name:Trifluoro-methanesulfonic acid 2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl ester

Cas No:154703-73-8

R&D Labs maybe for 154703-73-8

shijiazhuang baisheng chem co.; ltd

Contact:86-0311-80790826

Address:shijiazhuang hebei
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
Anhui Jiatiansen Agrochemical Co.,Ltd

Contact:15366811918

Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
TIANJIN FESTO CHEMICAL CO.,LTD(expird)

Contact:86-22-25814570

Address:No.12th,5th Ave.,TEDA,Tianjin,China

Relevant to this article

A comparative study of the reactivity of the lightly stabilized cluster [Os₃(CO)8{μ₃-Ph₂PCH₂P(Ph)C ₆H₄}(μ-H)] towards tri(2-thienyl)-,tri(2-furyl)- and triphenyl-phosphine

Doi:10.1016/j.jorganchem.2013.08.027
(2014)
Well-defined air-stable palladium HASPO complexes for efficient Kumada-Corriu cross-couplings of (Hetero)aryl or alkenyl tosylates

Doi:10.1002/chem.201002386
(2011)
Convenient synthesis of new N-3-substituted pyrido[1′,2′:1,5] pyrazolo[3,4- d ]pyrimidine-2,4(1 H,3 H)-dione derivatives

Doi:10.1055/s-0033-1338514
(2013)
ANTITUBERCULOTIC 4'-CYCLOHEXYLTHIOBENZANILIDES: COMBINATION OF FREE-WILSON METHOD IN QSAR WITH TOPLISS APPROACH

Doi:10.1135/cccc19930205
(1993)
Nonlinear Optical Chromophores with Aggregation Induced Emission Enhancement Based on 2-N,N-Dibutylamino-4-Phenyl Thiazole with FMR Characteristics

Doi:10.1007/s10895-018-2311-7
(2019)
Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy

Doi:10.1021/ja903879w
(2009)

Article Doi