Collection of Czechoslovak Chemical Communications p. 205 - 212 (1993)
Update date:2022-08-05
Topics:
Waisser, Karel
Kubicova, Lenka
Odlerova, Zelmira
On the basis of a preliminary study of antimycobacterial activity of thiobenzanilides against Mycobacterium kansasii, a group of 4'-cyclohexylthiobenzanilides have been prepared which exhibit a significant activity against the microorganism mentioned.The whole set of 35 thiobenzanilides was tested with Mycobacterium tuberculosis, and on the basis of the QSAR analysis conclusions have been made with regard to prognostics of structures suitable for further studies.The problem was solved by the method by Free and Wilson combined with the Topliss approach and by a Hansch type analysis.
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