Reversal of stereoselectivity in the Evans aldol reaction of α,α-difluoro and α,α,α-trifluoro carbonyl compounds

Article abstract of DOI:10.1016/S0040-4039(00)61475-2

The Evans aldol reaction of hexafluoroacetone and trifluoroacetaldehyde causes reversal of stereoselectivity. The boron enolate derived from oxazolidinone 1 reacts with trifluoroacetaldehyde to give anti and "non-Evans" syn aldols with stereoselectivities