Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33-C42 fragment and further coupling to afford the C22-C42 carbon unit

Article abstract of DOI:10.1016/S0040-4039(00)73058-9

A short and stereoselective synthesis of the C₃₃-C₄₂ fragment 3 of rapamycin and its coupling with the previously prepared C₂₂-C₃₂ fragment 2 is described. The synthesis of 3 involves the preparation of enantiom