Synthesis and anticancer activity of 2-substituted 2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one and its 2-oxide derivatives

DOI: 10.1002/ardp.19943270408

Source and publish data:

Archiv der Pharmazie p. 233 - 236 (1994)

Update date:2022-07-30

Topics:

Authors:

Kostka Kostka

Porada Porada

Graczyk Graczyk

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/ardp.19943270408

As a result of the reaction of salicylic amide with PCl₃ and POCl₃ 2-chloro-2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one (1) and its 2-oxide 2 are obtained. Compounds 1 and 2 form amides with amines in 2-position. Antineoplastic action of the derivatives containing the bis(2-chloroethyl)amide group in 2-position was found.

Full text of DOI:10.1002/ardp.19943270408

Products guided by the article

Product name:2-[bis(2-chloroethyl)amino]-2,3-dihydro-4H-1,3,2-benzoxazaphosphinin-4-one

Cas No:156454-77-2

R&D Labs maybe for 156454-77-2

Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Chengdu Shengnuo Biological Technology Co., Ltd.

Contact:86-028-85275045

Address:Sichuan Province Chengdu hi tech Zone Tianfu Avenue North of 1480
Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province
Xian Changyue Biological Technology Co., Ltd.

website:https://www.xachangyue.com/

Contact:+86-029-88211911

Address:Keji Road NO.70
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina

Relevant to this article

Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues

Doi:10.3390/molecules19033638
(2014)
Straightforward access to aryl-substituted/fused 1,3-dithiole-2- chalcogenones by Cu-catalyzed C-S coupling between aryl iodides and zinc-thiolate complex (TBA)₂[Zn(DMIT)₂]

Doi:10.1039/c3ra41349g
(2013)
A novel necroptosis inhibitor - Necrostatin-21 and its SAR study

Doi:10.1016/j.bmcl.2013.06.073
(2013)
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation

Doi:10.1021/jm4006753
(2013)
Enantioselective synthesis of (+)-(1R,2S)-allocoronamic acid

Doi:10.1016/S0040-4039(00)61159-0
(1992)
O-ACYLATION OF KETOXIMES OF THE FURAN AND THIOPHENE SERIES IN THE LIQUID-SOLID BODY SYSTEM UNDER INTERPHASE CATALYSIS CONDITIONS

Doi:10.1007/BF01169629
(1994)

Article Doi