Enantioselective synthesis of the (syn,anti)-1-amino-2,3-diol subunit of renin inhibition by reaction of β-lactams with a Grignard reagent

DOI: 10.1016/0040-4039(95)00824-V

Source and publish data:

Tetrahedron Letters p. 4543 - 4546 (1995)

Update date:2022-08-03

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Authors:

Spero Spero

Kapadia Kapadia

Farina Farina

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Article abstract of DOI:10.1016/0040-4039(95)00824-V

A new approach to the BOC-protected amino diol 1a via the opening of 3,4-cis-disubstituted β-lactam 3 with isobutylmagnesium chloride is described. Nonracemic β-lactam 3 could be obtained by enzymatic resolution of the 3-acetoxy-β-lactam 4 or from a chira

Full text of DOI:10.1016/0040-4039(95)00824-V

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