Molecules p. 12119 - 12143 (2013)
Update date:2022-08-04
Topics: Syntheses Precursors Positron Emission Tomography (PET) Tracers Melanin-concentrating hormone receptor 1 (MCHR1) Reference compounds [11C]SNAP-7941 and [18F]FE@SNAP
Schirmer, Eva
Shanab, Karem
Datterl, Barbara
Neudorfer, Catharina
Mitterhauser, Markus
Wadsak, Wolfgang
Philippe, Cecile
Spreitzer, Helmut
The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor's eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [11C]SNAP-7941 and [18F] FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.
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(2013)