A new, general entry to 4-substituted indoles. Synthesis of (S)-(-)-pindolol and (±)-chuangxinmycin

DOI: 10.1016/0040-4039(93)85109-A

Source and publish data:

Tetrahedron Letters p. 489 - 492 (1993)

Update date:2022-08-03

Topics: Synthesis Enantiomer Chirality Indole

Authors:

Ishibashi, Hiroyuki

Tabata, Takashi

Hanaoka, Kyoko

Iriyama, Hiroko

Akamatsu, Susumu

Ikeda, Masazumi

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Article abstract of DOI:10.1016/0040-4039(93)85109-A

A new method for synthesis of 4-substituted indoles has been developed by using the 7-arylthio-6-7-dihydroindol-4(5H) one 5 as a common intermediate. The method was applied to the synthesis of (S)-(-)-pindolol (11) and (±)-chuangxinmycin (16).

Full text of DOI:10.1016/0040-4039(93)85109-A

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