Synthesis of a Key Intermediate for Preparation of 4,5-Didehydro Prostaglandins containing an Allenyl Side-chain Group via Two-component Coupling Process. Synthesis of Enprostil

DOI: 10.1039/c39940001251

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Journal of the Chemical Society. Chemical communications p. 1251 - 1252 (1994)

Update date:2022-08-03

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Authors:

Ono, Naoya

Kawanaka, Yasufumi

Yoshida, Yukio

Sato, Fumie

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Article abstract of DOI:10.1039/c39940001251

Enone 8, a key intermediate in the preparation of 4,5-didehydro prostaglandins via a two component coupling process, is prepared efficiently from readily available enone 6; the synthesis of enprostil, an antiulcer agent developed by Syntex, using enone 8 is also described.

Full text of DOI:10.1039/c39940001251

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