Synthesis of a Key Intermediate for Preparation of 4,5-Didehydro Prostaglandins containing an Allenyl Side-chain Group via Two-component Coupling Process. Synthesis of Enprostil

DOI: 10.1039/c39940001251

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1251 - 1252 (1994)

Update date:2022-08-03

Topics:

Authors:

Ono, Naoya

Kawanaka, Yasufumi

Yoshida, Yukio

Sato, Fumie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39940001251

Enone 8, a key intermediate in the preparation of 4,5-didehydro prostaglandins via a two component coupling process, is prepared efficiently from readily available enone 6; the synthesis of enprostil, an antiulcer agent developed by Syntex, using enone 8 is also described.

Full text of DOI:10.1039/c39940001251

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester

Cas No:157543-66-3

R&D Labs maybe for 157543-66-3

Nanjing lanbai chemical Co.,Ltd.

Contact:+86-25-85499326

Address:Room 908, 9F Taiyue Building,No.285 Heyan Road
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
CGeneTech (Suzhou, China) Co., Ltd.

Contact:+86-512-62956962

Address:Room 101，Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Melone Pharmaceutical Co., ltd

Contact:+86-411 82593920, 82593631

Address:No 232, JInma Roda, Development Zone, Dalian, China
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China

Relevant to this article

Synthesis, Chemical Property, and Cytotoxicity of the Carzinophilin Congeners Carrying a 2-(1-Acylamino-1-alkoxycarbonyl)methylidene-1-azabicyclo<3.1.0>hexane System

Doi:10.1016/S0040-4039(00)76798-0
(1994)
C-, N- and C,N-Organostannyl Tetrazoles: Synthesis, Characterisation and Reactivity

Doi:10.1039/DT9940002135
(1994)
Palladium-Catalyzed C-H Activation and Cyclization of Anilides with 2-Iodoacetates and 2-Iodobenzoates: An Efficient Method toward Oxindoles and Phenanthridones

Doi:10.1055/s-0035-1561856
(2016)
Reactions of [Pt₂(μ-S)₂(PPh₃)₄] with Group 6 and 7 metal carbonyls; Crystal structure of the apparently unsaturated heterometallic complex [Pt₂Re(μ₃-S)₂(PPh₃) ₄(CO)₃]⁺

Doi:10.1016/S0022-328X(99)00640-3
(2000)
SO-Photoextrusion of 7-Thiabicyclo<2.2.1>hept-2-ene 7-Oxides

Doi:10.1246/bcsj.67.1886
(1994)
Novel juvenoids of the 2-(4-hydroxybenzyl)cyclohexan-1-one series

Doi:10.1002/hlca.19940770210
(1994)

Article Doi