Journal of the Chemical Society. Chemical communications p. 1147 - 1150 (1994)
Update date:2022-08-03
Topics: Organic synthesis Cytotoxic activity Swinholide A Convergent approach Stereoselective construction
Patron, A. P.
Richter, P. K.
Tomaszewski, M. J.
Miller, R. A.
Nicolaou, K. C.
A strategy for a total synthesis of the cytotoxic dimeric macrolide swinholide A (1, Scheme 1) is outlined and a stereoselective construction of the suitably functionalized C3-C17 fragment 4, starting with building blocks 6, 7, 9 and 10 is described.
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