European Journal of Medicinal Chemistry p. 541 - 551 (2014)
Update date:2022-09-26
Topics:
Pham, Ngoc B.
Deydier, Sophie
Labaied, Mehdi
Monnerat, Severine
Stuart, Kenneth
Quinn, Ronald J.
The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).
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