Synthesis and biological activity of N(ω)-hemiphthaloyl-α,ω- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin

Article abstract of DOI:10.1021/jm00040a008

Analogues of N(α)-(4-amino-4-deoxypteroyl)-N(δ)-(hemiphthaloyl)-L- ornithine (PT523) with 3',5'-dichloro substitution in the p-aminobenzoyl moiety or with one less or one more CH₂ group in the amino acid moiety were synthesized and tested as in