Discovery of CP-199,330 and CP-199,331: Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity

DOI: 10.1016/S0960-894X(99)00461-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2773 - 2778 (1999)

Update date:2022-08-02

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Authors:

Chambers

Marfat Marfat

Antognoli

Cheng Cheng

Damon Damon

Kuperman

Liston Liston

Mebus Mebus

Pillar Pillar

Shirley Shirley

Watson Watson

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Article abstract of DOI:10.1016/S0960-894X(99)00461-8

CP-199,330 (3) and CP-199,331 (4) are cysLT₁ receptor antagonists that are equipotent to marketed cysLT₁ receptor antagonists zafirlukast and pranlukast, show good pharmacokinetics in rats and monkeys, and are devoid of liver toxicity in monkeys as seen in CP-85,958 (1).

Full text of DOI:10.1016/S0960-894X(99)00461-8

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