Stereoselective Amination of Chiral Enolates: Synthesis of enantiomerically pure α,β-Diamino Acids, Chiral Key Compounds in the Synthesis of Conformationally Constrained Peptido- and Non-peptidomimetics

Article abstract of DOI:10.1016/0957-4166(95)00368-Y

This work describes an efficient synthesis of enantiomerically pure (R)-2-aminomethylalanine, (R)-2-aminomethylnorvaline, (R)-2-aminomethylvaline, (R)-2-aminomethylleucine and (R)-2-aminomethylphenylalanine by electrophilic amination of chiral 2-cyanoeste