Guanabenz-related amidinohydrazones: potent non-azole inhibitors of aldosterone biosynthesis

DOI: 10.1016/0223-5234(94)90040-X

Source and publish data:

European Journal of Medicinal Chemistry p. 223 - 232 (1994)

Update date:2022-07-30

Topics:

Authors:

Soll, R.M.

Dollings, P.J.

Mitchell, R.D.

Hafner, D.A.

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Article abstract of DOI:10.1016/0223-5234(94)90040-X

A new series of potent, guanabenz-derived, non-steroidal aldosterone biosynthesis inhibitors are presented.Salient features of the structure-activity relationship indicate the requirement of a hydrophobic core, presence of a hydrophilic (or basic) periphe

Full text of DOI:10.1016/0223-5234(94)90040-X

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