Guanabenz-related amidinohydrazones: potent non-azole inhibitors of aldosterone biosynthesis

DOI: 10.1016/0223-5234(94)90040-X

Source and publish data:

European Journal of Medicinal Chemistry p. 223 - 232 (1994)

Update date:2022-07-30

Topics:

Authors:

Soll, R.M.

Dollings, P.J.

Mitchell, R.D.

Hafner, D.A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(94)90040-X

A new series of potent, guanabenz-derived, non-steroidal aldosterone biosynthesis inhibitors are presented.Salient features of the structure-activity relationship indicate the requirement of a hydrophobic core, presence of a hydrophilic (or basic) periphe

Full text of DOI:10.1016/0223-5234(94)90040-X

Products guided by the article

Product name:(4-Chloro-phenyl)-(2,2-dimethyl-2H-chromen-6-yl)-methanol

Cas No:158257-64-8

R&D Labs maybe for 158257-64-8

Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China
SunaTech Inc.

Contact:+86 512 6287 2180

Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Tractus Company Limited

Contact:+852-8198 2399

Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Chuzhou Baiao Biologhy S&T Co., Ltd.

Contact:+86-25-83212599；+86-25-83212699 13705185959

Address:Room 905, Tianzheng International Platza, No.399, Zhongyang Road ,Nanjing, Jiangsu Province, China
JIEJIE GROUP CO.,LTD.

Contact:+86 021-51698675

Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China

Relevant to this article

Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone

Doi:10.1080/14786419.2020.1739679
(2021)
New heterocycles based on tetramethylol glycoluril

Doi:10.1134/S1070363214020339
()
Structural reevaluation of the electrophilic hypervalent iodine reagent for trifluoromethylthiolation supported by the crystalline sponge method for x-ray analysis

Doi:10.1002/anie.201310897
(2014)
Formation of a stable cyclopropenylium betaine

Doi:10.1021/ja00126a026
(1995)
Synthesis and anti-BVDV activity of novel δ-sultones in vitro: Implications for HCV therapies

Doi:10.1016/j.bmcl.2014.03.012
(2014)
Synthesis and Characterisation of Porphyrazinoctamine Derivatives: X-Ray Crystallographic Studies of <2,3,7,8,12,13,17,18-Octakis(dibenzylamino)porphyrazinato>magnesium(II) and < 2,3,7,8,12,13,17,18-Octakisporphyrazinato>nickel(II)

Doi:10.1039/c39940002095
(1994)

Article Doi