Nucleophilic Trifluoromethylthiolation of Alkyl Chlorides, Bromides and Tosylates

DOI: 10.1002/cjoc.201500905

Source and publish data:

Chinese Journal of Chemistry p. 495 - 504 (2016)

Update date:2022-08-04

Topics:

Authors:

Xu, Chunfa

Chen, Qingyun

Shen, Qilong

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Article abstract of DOI:10.1002/cjoc.201500905

A direct nucleophilic trifluoromethylthiolation of alkyl chlorides, bromides and tosylates with AgSCF₃ was described. It was found that the presence of nBu₄NI or a combination of nBu₄NI/nBu₄NBr significantly enhanced the reaction rates. The reaction conditions were mild, thus allowing the tolerance of a variety of functional groups.

Full text of DOI:10.1002/cjoc.201500905

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