Tetrahedron p. 7009 - 7018 (1994)
Update date:2022-07-29
Topics:
Sheffer-Dee-Noor, Shani
Ben-Ishai, Dov
Amidoalkylation of (2-chloroethyl)benzene or (2-bromoethyl)benzene with α-hydroxyhippuric acid and N-methoxycarbonyl α-hydroxyglycine, followed by dehydrohalogenation, affords N-protected p-vinylphenylglycines.Transformation of the vinyl group leads to N-methoxycarbonyl-p-<1-(methoxycarbonylamino)ethyl>phenylglycine, N-methoxycarbonyl-p-(epoxyethyl)phenylglycine, N-methoxycarbonyl-p-formylphenylglycine and N-methoxycarbonyl-p-carboxyphenylglycine.The deprotection of these compounds is described.
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Doi:10.1021/acs.orglett.5b01250
(2015)Doi:10.1002/chem.201402709
(2014)Doi:10.1039/DT9940002679
(1994)Doi:10.1246/cl.1982.1819
(1982)Doi:10.1007/BF00811522
(1994)Doi:10.1021/ja00099a097
(1994)