Synthesis of some dibenzodiazepine derivatives as potent and m2-selective antimuscarinic compounds

Article abstract of DOI:10.1002/jhet.5570310416

Two series of 5-[[4-[4-(dialkylamino)butyl]-1-cyclohexyl]acetyl], and 5-[(dialkylamino)acyl]-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-o nes were synthesized as potential m2-selective ligands 1,2. Their affinity and selectivity for the muscarinic cholinergic receptor m-AChR subtypes were determined. Replacing a nitrogen with CH in the piperidine ring of 5-[[4-[4-(dialkylamino)butyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H-d ibenzo[b,e][1,4]diazepin-11-ones 3 significantly altered the affinity and selectivity to the muscarinic receptor subtypes.