Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors

DOI: 10.1021/jm960082v

Source and publish data:

Journal of Medicinal Chemistry p. 3217 - 3227 (1996)

Update date:2022-08-03

Topics:

Authors:

Cushman, Mark

Golebiewski, W. Marek

Graham, Lisa

Turpin, Jim A.

Rice, William G.

Fliakas-Boltz, Valerie

Buckheit Jr., Robert W.

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Article abstract of DOI:10.1021/jm960082v

Several novel alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors were synthesized. The most potent of these proved to be 3',3'-dibromo-4',4'-dimethoxy-5',5'-bis(methoxycarbonyl)-1,1-diphenyl-1- heptene (8). ADAM 8 inhibited

Full text of DOI:10.1021/jm960082v

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