Synthetic study on oscillatoxin D: Construction of the C1-C26 spiroether segment by intramolecular aldol condensation and Michael-type addition

DOI: 10.1016/S0040-4039(00)73355-7

Source and publish data:

Tetrahedron Letters p. 4361 - 4364 (1994)

Update date:2022-08-03

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Authors:

Toshima, Hiroaki

Goto, Takashi

Ichihara, Akitami

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Article abstract of DOI:10.1016/S0040-4039(00)73355-7

The C₁-C₇ segment (10) and the C₈-C₂₁ segment (14) of oscillatoxin D have been synthesized efficiently. The acyclic compound obtained by coupling of these two segments, has been converted into the C₁-C₂₆ spiroether (18) possessing the same stereogenic centers of oscillatoxin D. The construction of the spiroether has been achieved by intramolecular aldol condensation and Michael-type addition as key steps.

Full text of DOI:10.1016/S0040-4039(00)73355-7

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