A General Method for the Synthesis of Isatins: Preparation of Regiospecifically Functionalized Isatins from Anilines

DOI: 10.1016/0040-4039(94)85299-5

Source and publish data:

Tetrahedron Letters p. 7303 - 7306 (1994)

Update date:2022-08-02

Topics:

Authors:

Hewawasam, Piyasena

Meanwell, Nicholas A.

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Article abstract of DOI:10.1016/0040-4039(94)85299-5

A new method has been developed for regiospecific conversion of substituted anilines to isatins.The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with diethyl oxalate to furnish an α-ketoester.Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin.

Full text of DOI:10.1016/0040-4039(94)85299-5

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