
Tetrahedron Letters p. 7303 - 7306 (1994)
Update date:2022-08-02
Topics:
Hewawasam, Piyasena
Meanwell, Nicholas A.
A new method has been developed for regiospecific conversion of substituted anilines to isatins.The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with diethyl oxalate to furnish an α-ketoester.Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin.
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