Bioorganic and Medicinal Chemistry Letters p. 2149 - 2154 (1997)
Update date:2022-08-05
Topics:
Becker, Daniel P.
Nosal, Roger
Villamil, Clara I.
Gullikson, Gary
Moummi, Chafiq
Yang, Dai-Chang
Flynn, Daniel L.
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4, agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4, agonist in the series, with an EC50 of 217 nM.
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