Serotonin 5-HT4, agonist activity of a series of meso-azanoradamantane benzamides

DOI: 10.1016/S0960-894X(97)00408-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2149 - 2154 (1997)

Update date:2022-08-05

Topics:

Authors:

Becker, Daniel P.

Nosal, Roger

Villamil, Clara I.

Gullikson, Gary

Moummi, Chafiq

Yang, Dai-Chang

Flynn, Daniel L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00408-3

A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT₄, agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT₄, agonist in the series, with an EC₅₀ of 217 nM.

Full text of DOI:10.1016/S0960-894X(97)00408-3

Products guided by the article

Product name:Hexahydro-8-[(phenylmethoxy) imino]-2,6-methano-1H-pyrrolizine

Cas No:159996-17-5

R&D Labs maybe for 159996-17-5

Watson International Ltd

Contact:+44 (0)2036089360-31

Address:Chanceryhouse,Chancery Lan
Linyi Shengxin Pharmaceutical R&D Co., Ltd

Contact:+86-18653953873

Address:West First of Yufeng Road, Yishui County
Hongyi Import & Export CO.,LTD

Contact:86-13319649499

Address:Nanzheng Neighborhood Commitees, Chongwen Office, Yongding District
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China

Relevant to this article

Ring opening of benzoxazinones: An improved and efficient synthesis of clavatustides A & B

Doi:10.1016/j.tetlet.2017.07.059
(2017)
Alum as an efficient catalyst for the multicomponent synthesis of functionalized piperidines

Doi:10.1007/s11164-017-2979-3
(2017)
Stereoselective Synthesis of β-Oxygenated α-Hydroxyphosphonates by Lewis Acid-Mediated Stereoselective Hydrophosphonylation of α-Benzyloxy Aldehydes. An Application to the Synthesis of Phosphonic Acid Analogs of Oxyamino Acids

Doi:10.1021/jo00104a064
(1994)
Synthesis and rearrangement of dispiro[2.0.3.4]-, dispiro-[3.0.3.3]- and dispiro[2.1.3.3]undecanes-preferred C₄-C₅ over C₃-C₄ and C₄-C₃ over C₅-C₆ rearrangements

Doi:10.1016/S0040-4020(01)85700-8
(1994)
Chemoenzymatic dynamic kinetic resolution of primary amines using a recyclable palladium nanoparticle catalyst together with lipases

Doi:10.1021/jo500508p
(2014)
Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by in Situ Crystallization

Doi:10.1021/jacs.0c01739
(2020)

Article Doi