Serotonin 5-HT4, agonist activity of a series of meso-azanoradamantane benzamides

DOI: 10.1016/S0960-894X(97)00408-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2149 - 2154 (1997)

Update date:2022-08-05

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Authors:

Becker, Daniel P.

Nosal, Roger

Villamil, Clara I.

Gullikson, Gary

Moummi, Chafiq

Yang, Dai-Chang

Flynn, Daniel L.

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Article abstract of DOI:10.1016/S0960-894X(97)00408-3

A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT₄, agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT₄, agonist in the series, with an EC₅₀ of 217 nM.

Full text of DOI:10.1016/S0960-894X(97)00408-3

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