Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol

DOI: 10.1021/jm00043a005

Source and publish data:

Journal of Medicinal Chemistry p. 2655 - 2663 (1994)

Update date:2022-08-03

Topics:

Authors:

Li, Leping

Thomas, Sheela A.

Klein, Larry L.

Yeung, Clinton M.

Maring, Clarence J.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00043a005

Taxol (1) is considered a most exciting new drug in cancer chemotherapy.The promising antitumor activity of 9(R)-dihydrotaxol (3) encouraged us to further explore the structure-activity relationship of this new member of the taxane family.Studies indicate

Full text of DOI:10.1021/jm00043a005

Products guided by the article

Product name:(3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone

Cas No:160237-96-7

R&D Labs maybe for 160237-96-7

Nanjing Xi Ze Biological Technology Co., Ltd

Contact:86-025-66023220

Address:Address: Nanjin Qixia District Maigaoqiao R & D base in Pioneer Park Chun Yin Road 18-A928
Huangshan Honghui Pharm Technology Co., Ltd.(expird)

website:http://www.honghuichem.com

Contact:18855958372

Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
Zhejiang Kangfeng Chemical Co.,LTD.

Contact:+86-579-86709687

Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Suzhou Jingye Medicine & Chemical Co., Ltd

Contact:+86-512-66658588

Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai

Relevant to this article

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases

Doi:10.1016/j.bmcl.2014.02.075
(2014)
Tunable Phosphine-Triggered Cascade Reactions of MBH Derivatives and 3-Acyl-2H-chromen-2-ones: Highly Selective Synthesis of Diverse Chromenones

Doi:10.1002/ejoc.201301358
(2014)
Mechanistic study of glycosylation using a prop-1-enyl donor

Doi:10.1021/jo301664c
(2013)
Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents

Doi:10.1016/j.bmc.2014.11.015
(2015)
Novel synthesis of carbohydrate fused α-amino γ-lactams and glycopeptides by NIS mediated ring opening of donor-acceptor substituted cyclopropanes

Doi:10.1016/j.carres.2014.02.022
(2014)
Self-assembly and (hydro)gelation triggered by cooperative π-π And unconventional C-H×××X hydrogen bonding interactions

Doi:10.1002/anie.201307806
(2014)

Article Doi