The construction of polysubstituted aromatic core derivatives via a cycloaddition/oxidative aromatization sequence from quinone and β-enamino esters

Article abstract of DOI:10.1002/adsc.201300892

An unexpected strategy has been discovered for the construction of polysubstituted aromatic core derivatives from the reaction of quinones or N-substituted maleimides with b-enamino esters by a cycloaddition/oxidative aromatization sequence that provides products contrary to those delivered by the Nenitzescu reaction. The current method provides a highly favorable synthetic strategy for the efficient construction of important therapeutic agents containing polysubstituted aromatic core structures.