The stereocontrolled synthesis of 1,2-trans hexopyranosyl nucleosides via a novel anomeric activation

Article abstract of DOI:10.1016/0040-4020(96)00611-4

The coupling of 2-(2',3',4',6'-tetra-O-benzyl-β-D-hexopyranosyloxy)-3-methoxypyridin e as well as 2-(2',3',4',6'-tretra-O-benzyl-β-D-hexopyranosyl)-thiopyridylcarbona te, with silylated pyrimidine bases by activation with trimethylsilyl trifluoromethanesulfonate and silver triflate respectively afforded the corresponding 1,2-trans nucleosides with high selectivity.