Advanced Synthesis and Catalysis p. 3517 - 3521 (2013)
Update date:2022-08-02
Topics:
Correia, Camille A.
McQuade, D. Tyler
Seeberger, Peter H.
A copper(I)/N-heterocyclic carbene complex-catalyzed addition of terminal alkynes to trifluoromethyl ketones at low loading is described. The developed process functions well using a range of terminal alkynes but functions best when an aryl trifluoromethyl ketone is used. This substrate scope is well-suited for the production of active pharmaceutical ingredients (APIs) such as efavirenz. In this vein, we demonstrate that the described method can be translated into a flow process laying the framework for a completely continuous synthesis of efavirenz in the future. Copyright
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