Iodine-Mediated Difunctionalization of Imidazopyridines with Sodium Sulfinates: Synthesis of Sulfones and Sulfides

Article abstract of DOI:10.1021/acs.joc.7b02734

Novel iodine-induced sulfonylation and sulfenylation of imidazopyridines have been described using sodium sulfinates as the sulfur source. This strategy enables highly selective difunctionalization of imidazo[1,2-a]pyridine to access sulfones and sulfides in good yields. A wide range of substrates and functional groups were well-tolerated under optimized conditions. Moreover, control experiments have been conducted, indicating a radical pathway involved in the reaction mechanisms.

Full text of DOI:10.1021/acs.joc.7b02734

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Article
Iodine-Mediated Difunctionalization of Imidazopyridines
with Sodium Sulfinates: Synthesis of Sulfones and Sulfides
Yu-Jing Guo, Shuai Lu, Lu-Lu Tian, En-Ling Huang, Xin-Qi Hao, Xinju Zhu, Tian Shao, and Mao-Ping Song
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.7b02734 • Publication Date (Web): 16 Dec 2017
Downloaded from http://pubs.acs.org on December 16, 2017
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