MACROCYCLES WITH SULFIDE AND AMINE BINDING SITES AS CHIRAL LIGANDS FOR NICKEL CATALYZED CROSS COUPLING OF A GRIGNARD REAGENT WITH VINYL BROMIDE

Article abstract of DOI:10.1016/S0040-4039(00)98674-X

Syntethic routes to macrocycles derived from (S)-phenyl alanine and (S)-cysteine have been developed.The catalyzed coupling of the Grignard reagent of 1-chloro-1-phenylethane and vinyl bromide in the presence of these ligands proceeds usually in good yields and in enantiomeric excesse (e.e.) of up to 46percent.