Progress toward a Novel C-Terminal Helix Capping Principle: Synthesis and Properties of (S)-α-(2-Aminoethyl)-Methionine

Article abstract of DOI:10.1016/S0040-4039(00)74395-4

(S)-α-(2-aminoethyl)-methionine 9 (s)-2,4-diamino-2-(3-thiabutyl)-butanoic acid) is synthesized in three steps from 1-benzoyl-2-tert-butyl-5-(3-thiabutyl)-oxazolidin-4-one.Neighboring group reactions of peptide derivatives of 9 are described.