Chemistry - A European Journal p. 3135 - 3141 (2014)
Update date:2022-07-30
Topics:
Pospech, Jola
Tlili, Anis
Spannenberg, Anke
Neumann, Helfried
Beller, Matthias
A ruthenium-catalyzed carbonylative Ci£H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)i£C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. Ci£ H bond functionalization: A ruthenium-catalyzed carbonylative Ci£H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) i£C(sp2) bond formation has been achieved.
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