European Journal of Medicinal Chemistry p. 364 - 382 (2014)
Update date:2022-08-15
Topics:
Reichelt, Andreas
Bailis, Julie M.
Bartberger, Michael D.
Yao, Guomin
Shu, Hong
Kaller, Matthew R.
Allen, John G.
Weidner, Margaret F.
Keegan, Kathleen S.
Dao, Jennifer H.
The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.
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