A new route for protected amino alcohols from (R)-glycidol. Copper(I) mediated alkylation of 4-tosyloxymethyl-2-oxazolidinone

DOI: 10.1246/bcsj.67.3363

Source and publish data:

Bulletin of the Chemical Society of Japan p. 3363 - 3365 (1994)

Update date:2022-08-04

Topics:

Authors:

Iwama Iwama

Katsumura

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Article abstract of DOI:10.1246/bcsj.67.3363

The reaction of (S)-4-tosyloxymethyl-2-oxazolidinone, which was synthesized from (R)-glycidol through (R)-4-benzoyloxymethyl-2-oxazolidinone, with various lithium dialkylcuprate(I)s in THF proceeded smoothly to afford the corresponding protected amino alcohol derivatives in good yield.

Full text of DOI:10.1246/bcsj.67.3363

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