A new route for protected amino alcohols from (R)-glycidol. Copper(I) mediated alkylation of 4-tosyloxymethyl-2-oxazolidinone

Article abstract of DOI:10.1246/bcsj.67.3363

The reaction of (S)-4-tosyloxymethyl-2-oxazolidinone, which was synthesized from (R)-glycidol through (R)-4-benzoyloxymethyl-2-oxazolidinone, with various lithium dialkylcuprate(I)s in THF proceeded smoothly to afford the corresponding protected amino alcohol derivatives in good yield.