SYNTHESIS OF N1'-(METHYL)NALTRINDOLE (MeNTI): A RADIOLIGAND FOR POSITRON EMISSION TOMOGRAPHIC STUDIES OF DELTA OPIOID RECEPTORS

DOI: 10.1002/jlcr.2580360206

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 137 - 146 (1995)

Update date:2022-08-05

Topics:

Authors:

Lever, John R.

Kinter, Chris M.

Ravert, Hayden T.

Musachio, John L.

Mathews, William B.

Dannals, Robert F.

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Article abstract of DOI:10.1002/jlcr.2580360206

A delta opioid receptor antagonist, N1'-methylnaltrindole (MeNTI), has been labeled with carbon-11.The precursor for radiolabeling was prepared in 71percent yield by benzylation of the phenolic moiety of naltrindole.Alkylation of the indole nitrogen using

Full text of DOI:10.1002/jlcr.2580360206

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