Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1

DOI: 10.1016/j.ejmech.2016.06.026

Source and publish data:

European Journal of Medicinal Chemistry p. 185 - 195 (2016)

Update date:2022-07-30

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Authors:

?imon, Petr

Baszczyňski, Ond?ej

?aman, David

Stepan, George

Hu, Eric

Lansdon, Eric B.

Jansa, Petr

Janeba, Zlatko

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Article abstract of DOI:10.1016/j.ejmech.2016.06.026

To elucidate the structure-geometry-activity relationship in diarylpyrimidine family (DAPYs) containing carbonyl linker between the central pyrimidine core and phenyl type B-arm, a series of (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones wa

Full text of DOI:10.1016/j.ejmech.2016.06.026

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