A simple synthesis of new push-pull substituted imidazoles by chemoselective nucleophilic attack of α-cyano epoxides

Article abstract of DOI:10.1016/0040-4039(94)02337-B

A chemoselective reaction of amidines orguanidines with α-cyano epoxides leads to new 4-amino-5-carbethoxy or 4-hydroxy-5-cyano or 4-carbethoxy-5-aryl-imidazoles depending an the steric hindrance of the epoxides and on the reaction medium.