Tetrahedron p. 13881 - 13894 (1996)
Update date:2022-07-30
Topics:
Iwasawa, Yoshikazu
Shibata, Jun
Nonoshita, Katsumasa
Arai, Sachie
Masaki, Hitoshi
Tomimoto, Koji
A novel class of squalene synthase inhibitors (J-104,118 and J-104,123) were synthesized efficiently. An amine intermediate 1 was synthesized using two distinct methods. First, the racemic amine 1 was synthesized diastereoselectively using a key reaction consisting of the stereo-controlled reduction of the ketone 7 by L-Selectride. Second, the optically active amine 1 was synthesized efficiently and enantioselectively using Sharpless dihydroxylation as a key reaction. A stereo-controlled method for synthesizing J-104,123 was developed starting from a commercially available methyl (R)-3-hydroxybutyrate.
View MoreSuzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Contact:852-29282288
Address:HONGKONG
Shanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Contact:86-575-86132822,86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Doi:10.1139/v67-165
(1967)Doi:10.1002/ejoc.202000006
(2020)Doi:10.1002/adsc.201301171
(2014)Doi:10.1007/BF01167142
(1967)Doi:10.1016/0040-4039(94)02317-5
(1995)Doi:10.1002/anie.201400602
(2014)