Bioorganic and Medicinal Chemistry Letters p. 1671 - 1676 (1997)
Update date:2022-07-30
Topics:
Lin, Yang-I
Bitha, Panayota
Sakya, Subas M.
Strohmeyer, Timothy W.
Li, Zhong
Lee, Ving J.
Lang Jr., Stanley A.
Yang, Youjun
Bhachech, Niraja
Weiss, William J.
Petersen, Peter J.
Jacobus, Nilda V.
Bush, Karen
Testa, Raymond T.
Tally, Francis P.
A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice.
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(1997)
