Efficient cleavage of terminal acetonide group: Chirospecific synthesis of 2,5-Dideoxy-2,5-Imino-D-Mannitol

Article abstract of DOI:10.1016/0040-4039(94)88373-4

Dowex 50W-X8 was efficient catalyst for selective cleavage of terminal actonide including acid-sensitive multifunctional groups. A facile and economically synthesis of DMDP (2,5-dideoxy-2,5-imino-D-mannitol) is described via selective hydrolysis and intramolecular nucleophilic amination.