Studies directed toward the synthesis of (+)-mycotrienin. I. Asymmetric synthesis of the C9-N21 aromatic synthon

Article abstract of DOI:10.1016/0040-4039(94)02427-D

The asymmetric synthesis of the C₉-N₂₁ fragment of (+)-mycotrienin I is described employing chiral allylsilane bond construction methodology for the installation of the C₁₂-C₁₃ absolute stereochemical relationships. In this convergent synthesis the construction of the C₉-C₁₆ and C₁₇-N₂₁ aromatic synthon subunits and their coupling through a lithio dithiane alkylation strategy are detailed.