Regiospecific Intramolecular Ring-Closure of Heterocumulene-Substituted Indoles: Formation of γ-Carbolines and Pyrimidoindoles.

Article abstract of DOI:10.1016/0040-4039(94)02399-V

2-(Indol-2-yl)ethyl heterocumulenes undergo ring-closure under acid, basic and thermal conditions to give either dihydro γ-carbolines or dihydropyrimido<3,4-a>indoles in a completeley regiospecific fashion.The mode of cyclization strongly depends on the c