Stereoselective total synthesis of topographically constrained designer amino acids: 2',6'-dimethyl-β-methyltyrosines

Article abstract of DOI:10.1016/0040-4020(94)00996-8

The constrained aromatic α-amino acid 2',6'-dimethyl-β-methyl tyrosine (Figure 1) was designed to provide specific local constraints to peptides or peptide mimetics. We report here methods for the total asymmetric synthesis of all four stereoisomers. The