Chiral Synthesis of L-γ-Carboxylgutamic Acid (L-Gla)

DOI: 10.1016/0040-4039(94)02418-B

Source and publish data:

Tetrahedron Letters p. 825 - 828 (1995)

Update date:2022-08-05

Topics:

Authors:

Schuerman, Marla A.

Keverline, Kathryn I.

Hiskey, Richard G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(94)02418-B

A two step synthesis involving the use of a chiral template, benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholine-carboxylate (5a), provides orthogonally protected L-Gla (9) in 60percent overall yield (>99percent ee), with no resolution required.

Full text of DOI:10.1016/0040-4039(94)02418-B

Products guided by the article

Product name:2-((3S,5S,6R)-4-Benzyloxycarbonyl-2-oxo-5,6-diphenyl-morpholin-3-ylmethyl)-malonic acid di-tert-butyl ester

Cas No:161990-12-1

R&D Labs maybe for 161990-12-1

shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai
Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Shandong LuZhou Amino Acid Co., Ltd

Contact:86-539-2218025

Address:yishui economic and technical development zone zhenxing south road
Sarchem Laboratories, Inc.

Contact:732.938.2777

Address:5012 Industrial Road Farmingdale, NJ 07727

Relevant to this article

Binding ability of first and second generation/carbazolylphenyl dendrimers with Zn(ii) tetraphenylporphyrin core towards small heterocyclic substrates

Doi:10.1039/c3ra45660a
(2014)
Olefin cross-metathesis: Studies towards the total synthesis of (+)-bitungolide F

Doi:10.1002/hlca.201300326
(2014)
Spectral, structural and quantum chemical computational and dissociation constant studies of a novel azo-enamine tautomer

Doi:10.1016/j.molstruc.2014.06.033
(2014)
Selective Synthesis of Tripyrranes, Tetrapyrranes, and Corroles

Doi:10.1002/ejoc.201501062
(2015)
Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA_A receptor agonists

Doi:10.1016/j.ejmech.2014.07.039
(2014)
Synthesis of 5'-O- and 3'-O-Nucleoside Carbamates.

Doi:10.1016/0040-4020(94)00948-T
(1995)

Article Doi