Direct, Stereoselective Synthesis of the Protected Paclitaxel (Taxol) Side Chain and High-yield Transformation to Paclitaxel

DOI: 10.1039/c39940002591

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 2591 - 2592 (1994)

Update date:2022-08-04

Topics: Stereoselective synthesis Chemical Reaction Experimental terms Stereoisomer Paclitaxel Chemical groups

Authors:

Kanazawa, Alice M.

Denis, Jean-Noel

Greene, Andrew E.

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Article abstract of DOI:10.1039/c39940002591

A short, efficient approach to the p-methoxybenzylidene-protected paclitaxel (Taxol) side chain through benzaldehyde benzoylimine-chiral enolate condensation, followed by DDQ-mediated oxazolidine formation and hydrolysis is described; the C-7-triethylsily

Full text of DOI:10.1039/c39940002591

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