N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases

DOI: 10.1016/j.bmc.2019.03.020

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1693 - 1703 (2019)

Update date:2022-08-04

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Authors:

Otrubova, Katerina

Chatterjee, Shreyosree

Ghimire, Srijana

Cravatt, Benjamin F.

Boger, Dale L.

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Article abstract of DOI:10.1016/j.bmc.2019.03.020

A series of N-acyl pyrazoles was examined as candidate serine hydrolase inhibitors in which the active site acylating reactivity and the leaving group ability of the pyrazole could be tuned not only through the nature of the acyl group (reactivity: amide

Full text of DOI:10.1016/j.bmc.2019.03.020

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