Asymmetric Synthesis of S-(+)-4-Amino-5-hexynoic Acid

Article abstract of DOI:10.1016/0957-4166(94)00380-T

4-Amino-5-hexynoic acid is efficiently synthesised in eight steps (overall yield 10percent) from commercially available (S)-glutamic acid.The key step was conversion of an aldehyde to an acetylene using diethylmethyldiazophosphonate.