Asymmetric Synthesis of S-(+)-4-Amino-5-hexynoic Acid

DOI: 10.1016/0957-4166(94)00380-T

Source and publish data:

Tetrahedron Asymmetry p. 239 - 244 (1995)

Update date:2022-09-26

Topics:

Authors:

McAlonan, Helena

Stevenson, Paul J.

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Article abstract of DOI:10.1016/0957-4166(94)00380-T

4-Amino-5-hexynoic acid is efficiently synthesised in eight steps (overall yield 10percent) from commercially available (S)-glutamic acid.The key step was conversion of an aldehyde to an acetylene using diethylmethyldiazophosphonate.

Full text of DOI:10.1016/0957-4166(94)00380-T

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