Application of Sodium Amalgam Reductive Elimination of Allylic Dibenzoates to the Total Synthesis of 5(S)-12(R) Leukotriene B4

Article abstract of DOI:10.1016/0040-4039(93)85078-B

A stereoselective synthesis of 5(S)-12(R) LTB₄ is described in this paper using a novel reaction, the sodium amalgam induced reductive elimination of allylic dibenzoates for the selective synthesis of the E,E,Z-triene moiety.The creation of the