The synthesis of 1-hydroxy-3-phenylsulphonylpiperidine-2-thione derivatives utilizing methylthiothiocarbonylation as the key original step

Article abstract of DOI:10.1016/0040-4020(94)01079-F

Three 1-hydroxy-3-phenylsulphonylpiperidine-2-thione derivatives have been prepared from methylphenylsulphone in five steps. The key step was the preparation of a dithioester which was achieved in a very high yield using nBuLi, CS₂, and MeI.