
Journal fur Praktische Chemie - Chemiker-Zeitung p. 12 - 17 (1995)
Update date:2022-07-30
Topics:
Ali, Syed Safdar
Khan, Khalid Mohammed
Echner, Hartmut
Voelter, Wolfgang
Hasan, Mashooda
Atta-ur-Rahman
Two new synthons, Fmoc-L-Arg(biphenyl-4-sulphonyl)-OH (8) and Fmoc-Arg(4-methoxy-3-t-butylbenzenesulphonyl)-OH (14), are prepared for the synthesis of arginine-containing peptides.These groups are cleaved by commonly employed trifluoroacetic acid and methanesulphonic acid.Kinetic studies reveal that extended bicyclic aromatic conjugation, as in biphenyl, slightly improves the acid lability compared to the electron-donating t-butyl group.
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